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Activators & Inhibitors
Chemical Modulators

U-18666A #68998

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other Image 1 - U-18666A

Chemical structure of U-18666A.

Product Usage Information

U-18666A is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 424.1 g/mol


Molecular Formula

C25H41NO2 • HCl

CAS 3039-71-2
Solubility Soluble in water at 20 mg/ml.


U-18666A is a cell permeable drug that inhibits cholesterol transport. This small molecule inhibits low density lipoprotein (LDL)-derived cholesterol transport, blocking cholesterol esterification, and suppressing LDL receptor activities (1). Studies have shown that impaired cholesterol trafficking is associated with neurological diseases such as Alzheimer’s disease (AD), Niemann-Pick disease type C (NPC), and atherosclerosis (2,3). The mechanisms of neurodegeneration for these diseases are mostly unknown so studies using U-18666A to simulate intracellular cholesterol accumulation may provide greater insight into these pathologies (2). Cholesterol levels play a role in the body’s response to viral infection and the ability of a virus to enter and replicate within a host cell, making U-18666A an important compound when studying different viral diseases (4).

  1. Liscum, L. and Faust, J.R. (1989) J Biol Chem 264, 11796-806.
  2. Koh, C.H. and Cheung, N.S. (2006) Cell Signal 18, 1844-53.
  3. Tabas, I. (2004) Cell Death Differ 11 Suppl 1, S12-6.
  4. Poh, M.K. et al. (2012) Antiviral Res 93, 191-8.
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 68998S
Product # Size Price
5 mg N/A

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