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59489
Losartan (potassium salt)
Activators & Inhibitors
Chemical Modulators

Losartan (potassium salt) #59489

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other Image 1 - Losartan (potassium salt)

Chemical structure of Losartan (potassium salt).

Product Usage Information

Losartan (potassium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.08 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at 4ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 461 g/mol
Purity

>99%

Molecular Formula

C22H22ClN6O • K

CAS 124750-99-8
Solubility Soluble in DMSO at 45 mg/ml or water at 45 mg/ml.

Background

Losartan (potassium salt) is a known angiotensin II receptor antagonist by selectively and competitively blocking the binding of the angiotensin II hormone (1). In clinical settings, it is useful as an antihypertensive agent and also displays neuroprotective effects against chronic fatigue stress (2,3). Losartan (potassium salt) inhibits collagen I synthesis and induces sirtuin 1 (SirT1) expression and activity (4,5).

  1. Chiu, A.T. et al. (1990) J Pharmacol Exp Ther 252, 711-8.
  2. McIntyre, M. et al. (1997) Pharmacol Ther 74, 181-94.
  3. Kumar, A. et al. (2015) Inflammopharmacology 23, 291-305.
  4. Diop-Frimpong, B. et al. (2011) Proc Natl Acad Sci U S A 108, 2909-14.
  5. Pantazi, E. et al. (2015) World J Gastroenterol 21, 8021-31.
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 59489S
Product # Size Price
59489S
50 mg N/A

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