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Activators & Inhibitors
Chemical Modulators

Captopril #53537

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other Image 1 - Captopril

Chemical structure of Captopril.

Product Usage Information

Captopril is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 217.3 g/mol


Molecular Formula


CAS 62571-86-2
Solubility Soluble in DMSO at 20 mg/ml or water at 20 mg/ml.


Captopril is a selective and reversible angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.022 μM (1). This small molecule selectively lowers angiotensin II, a hormone that when upregulated has been linked to increased hypertension, atherosclerosis, myocardial hypertrophy, and obesity (2-5). Captopril has also been shown to regulate inflammatory pathways as a reversible inhibitor of leukotriene A4 (LTA4) hydrolase, reducing leukotriene B4 synthesis (6).

  1. Fujita, H. and Yoshikawa, M. (1999) Immunopharmacology 44, 123-7.
  2. Bolterman, R.J. et al. (2005) Hypertension 46, 943-7.
  3. Vajapey, R. et al. (2014) Front Physiol 5, 439.
  4. Wu, C. et al. (2011) N Am J Med Sci (Boston) 4, 183-190.
  5. Putnam, K. et al. (2012) Am J Physiol Heart Circ Physiol 302, H1219-30.
  6. Orning, L. et al. (1991) J Biol Chem 266, 16507-11.
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 53537S
Product # Size Price
1 g N/A

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