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31403
Ascomycin (FK520)
Activators & Inhibitors
Chemical Modulators

Ascomycin (FK520) #31403

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other Image 1 - Ascomycin (FK520)

Chemical structure of Ascomycin (FK520).

Product Usage Information

Ascomycin (FK520) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 792 g/mol
Purity

>99%

Molecular Formula

C43H69NO12

CAS 104987-12-4
Solubility Soluble in DMSO at 50 mg/ml or ethanol at 50 mg/ml with slight warming.

Background

Ascomycin (FK520) is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus (1). A natural analogue of FK506, Ascomycin (FK520) has the ability to bind to FK506-binding protein 12 (FKBP12), inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells (NFAT) and other various substrates (2). Primarily described as an antifungal antibiotic, Ascomycin (FK520) has shown to be a potent immunosuppressant (IC50 = 0.55 nM) used to prevent the rejection of organ transplants and skin allografts (1,3). Ascomycin (FK520) displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action (2).

  1. Hatanaka, H. et al. (1988) J Antibiot (Tokyo) 41, 1592-601.
  2. Monaghan, P. et al. (2005) J Infect Dis 191, 1342-9.
  3. Arndt, C. et al. (1999) Microbiology 145 (Pt 8), 1989-2000.
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 31403S
Product # Size Price
31403S
5 mg N/A

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