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90826
Apicidin
Activators & Inhibitors
Chemical Modulators

Apicidin #90826

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other Image 1 - Apicidin

Chemical structure of Apicidin.

Product Usage Information

Apicidin is supplied as a lyophilized powder. For a 2 mM stock, reconstitute 1 mg of powder in 801 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 623.8 g/mol
Purity

>98%

Molecular Formula

C34H49N5O6

CAS 183506-66-3
Solubility Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml.

Background

Apicidin is a fungal metabolite, broad-spectrum antiprotozoal agent. This small molecule inhibits histone deacetylases (HDACs), known to moderate histone acetylation and chromatin folding during gene expression (1,2). Apicidin has been shown to irreversibly prevent the development of intracellular Apicomplexan parasites in vitro through HDAC inhibition (IC50 = 0.7 nM) (1). Research indicates that Apicidin inhibits tumor cell proliferation through gene expression changes of p21WAF1/Cip1 and gelsolin, and can cause cell cycle arrest in the G1 phase (2). Apicidin also decreases HIF-1α protein levels in human and mouse cell lines (3). HDAC2 has been recognized as a host immune response to the influenza A virus and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).

  1. Darkin-Rattray, S.J. et al. (1996) Proc Natl Acad Sci U S A 93, 13143-7.
  2. Han, J.W. et al. (2000) Cancer Res 60, 6068-74.
  3. Kim, S.H. et al. (2007) Oncol Rep 17, 647-51.
  4. Nagesh, P.T. et al. (2017) Front Microbiol 8, 1315.
  5. Walters, M.S. et al. (2009) J Virol 83, 11502-13.
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 90826S
Product # Size Price
90826S
1 mg N/A

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