Human Oncogenes & Tumor Suppressor Genes

Enumerates known oncogenes and tumor suppressors, with corresponding genetic alterations and cellular effects. Jump to a Signaling Pathway ------------------------ Akt Signaling Pathway Cell Cycle Control: G1/S Checkpoint Cell Cycle Control: G2/M DNA Damage Checkpoint Death Receptor Signaling Pathway GPCR Hedgehog Signaling In Vertebrates Notch Signaling Pathway Ras TGF-β Signaling Pathway Wnt/β-Catenin Signaling Other / TFs

Akt Signaling Pathway

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Akt	Point mutation, amplification, increased expression
	Bax	Point mutation
	FKHR/FoxO	Translocation
	PI3K	Point mutation
	Bcl2	Translocation
	INPP4B	Deletion, loss of heterozygosity, reduced expression
	LKB1	Point mutation
	PTEN	Point mutation, deletion
	TSC1/TSC2	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Cell Cycle Control: G1/S Checkpoint

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Abl	Translocation
	Cdk-2	Amplification, increased expression
	Cdk-4	Point mutation
	Cyclin D	Amplification, translocation
	Cyclin E	Amplification
	HPV-E7	Viral Infection
	p15	Point mutation
	p16	Point mutation
	p57	Point mutation
	Rb	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Cell Cycle Control: G2/M DNA Damage Checkpoint

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Aurora A	Amplification, increased expression
	HPV-E6	Viral Infection
	Mdm2	Amplification
	ARF	Point mutation
	ATM/ATR	Point mutation
	BRCA1	Point mutation
	Chk1	Point mutation
	Chk2	Point mutation
	DNA-PK	Point mutation
	FANCs	Point mutation
	HIPK2	Point mutation
	NBS1	Point mutation, deletion
	p53	Point mutation, deletion
	WT1	Point mutation, deletion
	MUTYH	Point mutation, deletion
	BLM	Point mutation, deletion
	RECQL4	Point mutation, deletion
	WRN	Deletion, insertion
	MMR genes	Point mutation, reduced expression
	XPA, C, D	Point mutation
	FBXW7	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Death Receptor Signaling Pathway

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Fas	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

GPCR

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Ga	Point mutation
	GPCR	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Hedgehog Signaling In Vertebrates

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Gli	Amplification, translocation
	Hedgehog	Point mutation
	Smo	Point mutation
	Ptch	Point mutation
	Su(Fu)	Point mutation
	EXT1,2	Point mutation, deletion, insertion

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Notch Signaling Pathway

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Notch	Translocation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Ras

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	B-Raf	Point mutation, amplification, increased expression
	Fos/Jun	Increased expression
	ILK	Increased expression
	Ras	Point mutation
	RTKs	Point mutation, translocation, amplification, increased expression
	Integrin	Deletion
	NF1	Point mutation, deletion
	NF2	Point mutation, deletion
	VHL	Point mutation
	FH	Point mutation
	SDH	Point mutation, deletion

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

TGF-β Signaling Pathway

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	Myc	Point mutation, amplification
	BMPR	Point mutation
	Smad2/3	Point mutation
	Smad4	Point mutation
	TGFβR	Point mutation
	MEN1	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Wnt/β-Catenin Signaling

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	β-catenin	Point mutation
	RAR	Amplification
	SOX	Amplification, increased expression
	Wnt1	Increased expression
	APC	Point mutation
	Axin	Point mutation
	α-catenin	Point mutation
	E-cadherin	Point mutation
	Wnt5A	Point mutation
	GPC3	Deletions, point mutation
	HRPT2	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function

Other / TFs

	Protein	Genetic Alterations	Evading Apoptosis	Self-Suffciency in Growth Status	Insensitivity to Anti-Growth Signals	Tissue Invasion & Metastasis	Sustained Angiogenesis
	TAL1	Translocation
	MLL	Translocation
	HOXs	Translocation, point mutation
	MITF	Amplification
	EVI1	Translocation
	BCL6	Translocation, point mutation
	HPC1	Point mutation

Table Key: Oncogenes Tumor Suppressors Indicates Protein Function