Basket Updated
0
Items added
Cytotoxicity is the ability of an exogenous agent to damage or kill cells. Measuring cytotoxicity can help determine the effect of drugs on cell viability.
Cell viability assays measure the population of live, viable cells within a sample. Typically, viability assays measure markers of cell health, including cellular metabolism, ATP levels, and cell proliferation.
This post explores common T cell types, their roles in modulating immune cell response, and T cell activation via interaction with cell surface receptors.
GPNMB is an attractive therapeutic target for antibody-based therapeutics, and is currently being evaluated for its potential in treating triple-negative breast cancer and other metastatic cancers. Let's explore the strategy behind one type of immunotherapeutics, antibody-drug conjugates (ADCs).
Learn about the antibodies, custom reagents, and ready-to-use cell assay kits to support your CAR-T therapy development.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Lymphoid lineage cells can be characterized using antibodies for cell type-specific markers, allowing cells to be visualized using flow cytometry or IHC.
The adaptive immune response uses antigen-specific receptors to detect foreign antigens with help from T cells, B cells, and NK T cells.
Interact with this CAR-T signaling pathway to learn how the combination of extracellular and intracellular domains, including CD8, CD28, 4-1BB, OX40, or CD27, exert antitumor effects.
Our immune system has the ability to detect and fight infectious pathogens. But over time, cancers can evolve and evade the immune response.
The innate immune response is your first line of defense against pathogens. It provides a quick response to pathogens by many mechanisms, including cytokine production and complement activation.
This interactive guide shows the most important cell and functional state markers for tumor-infiltrating immune cells in mice.
Harnessing the power of the immune system's T cells to attack and treat cancer is a promising research area that may lead to highly effective therapies.
Checkpoint inhibitors, targeted antibodies, adoptive cell therapy, and cancer vaccines are promising immunotherapies with recent therapeutic developments.
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.
Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.
We created a set of guides from the perspective of observing immune cells in intact tumor tissue. Given the technical constraints of multiplex IHC, we aimed to provide the minimum set of most well-established markers enabling identification of each cell type.
Given the limited but remarkable success of immune checkpoint blockade, recent efforts have been focused on identifying new targets for improving immunotherapy effectiveness in the immunosuppressive tumor microenvironment. One such target is T cell immunoreceptor with Ig and ITIM domains (TIGIT).
T cells are essential to cell-mediated immunity. Recognition of an antigen and engagement of a variable T cell receptor that is expressed on the cell surface leads to T cell activation.
This interactive guide shows the key cell and functional state markers for tumor-infiltrating immune cells in humans.Web Location: Immunology and Inflammation
Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer’s disease, Parkinson’s
This poster features various cellular components of the tumor microenvironment, with particular emphasis on tumor infiltrating lymphocytes and mechanisms of immune suppression.
In-depth characterization of immune checkpoints in the tumor microenvironment
Interact with this signaling pathway showing immune checkpoint regulation in the tumor microenvironment, including targets such as PD-L1, GITR, TIM-3, CTLA-4, OX40, and more.
Advancements in immunotherapeutics against cancer include receptor agonists, adoptive cell transfer, anti-cancer vaccines, and combination therapies.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Immunophenotyping is a technique that uses antibodies to allow the identification and quantification of particular cell types within a heterogenous population.
Neurodegeneration is marked by the progressive loss of neuronal function and structure, leading to cognitive disabilities such as dementia.
Immunophenotyping is a technique that uses antibodies to allow the identification and quantification of particular cell types within a heterogeneous population.